- Shoreline Farms
- Shutes Folly Island
- Slann Island
- Snake Island
- Snowden
- Sol Legare Island
- South Santee
- South Windermire
- Springfield
- Stafford Heights
- Steamboat Landing
- Stiles Point
- Stone Park
- Stono
- Stono Station
- Sylecope
- Sylvia Lane
- Saratt
- Shalimar
- Smith Ford
- State Line
- Sandy River
- Smith
- Springwood Lakes
- Stringfellow
- Shiloh
- Saint Paul
- Seloc
- Shad Moss village
- Silver